Comparison of quantitative and qualita- tive characteristics of the system von Willebrand factor — metalloprotease ADAMTS13 in patients with acute myocardial in farction and is chemic stroke

Introduction. The hemostasis system plays a key role in the pathogenesis of cardiovascular diseases. Aim — to evaluate changes quantitative and qualitative characteristics ADAMTS13 metalloprotease von Willebrand factor an tigen (vWF:Ag) patients with acute myocardial farction (AMI) is chemic stroke (IS). Patients methods. study cluded 110 aged 42–95 years (median age 64 years), which: 65 AMI 42–81 56 years) who had coronary artery thrombosis during giography, as well 45 IS 40–95 70 diagnosed cerebral thrombosis. All were tested for tigen, activity, tibodies vWF:Ag. Blood samples obtained giography (arterial venous blood) 24 120 hours after (venous blood). Results. In group AMI, crease values vWF:Ag dicator was revealed, which went beyond upper limit reference terval. IS, at beginning study, this within terval statistically significantly lower compared but creased peaked hours. When alyzing ADAMTS13:Ag dicator, it found that higher all points however, did not go both groups. At same time, ADAMTS13:AC dex ADAMTS13:AB dex. On contrary, patients, when IS. Conclusion. two pathogenetic models demonstrated absence relationship between or metalloprotease. can be considered reason decrease these patients.